As a colonial construct, the global drug control regime has undermined the rights of indigenous peoples (including the right to self determination, and to practice and revitalize their cultural traditions and customs), obliging all states to abolish traditional uses of coca, cannabis and opium by means of crop eradication and drug law enforcement. This webinar, which took place on the International Day of the World's Indigenous Peoples 2021, will shed light on the conflict between the drug control regime and Indigenous rights, and challenge prevailing narratives that these tensions are possible to reconcile while the UN retains the goal of a society free of drugs.